Method for growing crystals

Details Method for growing crystals Method for growing crystals

C - Chemistry, Metallurgy

30

B

C30B 28/00 (2006.01) C07K 1/30 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2344887

A high throughput crystallization methodology using 1,536 well microassay plate technology is described. The methodology uses mother-daughter plate technology with robotic control to deliver oil, unique crystallization cocktails, and a protein solution to each of the wells. This provides 1,536 unique microbatch crystallization experiments using as little as 6 mg of protein in 600 microliters of solution. The time required to deliver a protein solution to a prepared experiment plate is less than 10 minutes. A plate imaging system with a capacity of 28 microassay plates is also described. The imaging system digitally records the results of the experiments for later comparison to database results.

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