Method for identification of compound having antidepressant...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/09 (2006.01) C07K 14/705 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) A61K 45/00 (2006.01) A61P 25/24 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2606489

The purpose is to find a gene encoding a protein having a function equivalent to that of a G protein conjugated receptor (GPCR) and the protein and to provide a method for the identification of a compound capable of regulating the function and/or expression of the protein and an effective means for the prevention and/or treatment a disease associated with the gene or protein. DNA comprising the nucleotide sequence depicted in SEQ ID NO:1 or a complementary thereof; a homolog of the DNA; a protein encoded by the DNA; a vector carrying the DNA therein; a transformant bearing the vector therein; an antibody directed against the protein; a method for the identification of a compound capable of regulating the function and/or expression of the protein using any one of these substances; an ameliorating agent and a amelioration method for a depressive condition; a pharmaceutical composition; and a reagent kit.

L~objet de l~invention est de trouver un gène codant une protéine ayant une fonction équivalente à celle d~un récepteur conjugué à une protéine G (GPCR) et la protéine et de procurer un procédé pour l~identification d~un composé capable de réguler la fonction et/ou l~expression de la protéine et un moyen efficace pour la prévention et/ou le traitement d~une maladie associée avec le gène ou la protéine. L~ADN comprenant la séquence de nucléotide décrite dans SEQ ID NO:1 ou son complémentaire; un homologue de l~ADN; une protéine codée par l~ADN; un vecteur portant l~ADN à l~intérieur; un transformant portant le vecteur à l~intérieur; un anticorps dirigé contre la protéine ; un procédé pour l~identification d~un composé capable de réguler la fonction et/ou l~expression de la protéine en utilisant n~importe laquelle de ces substances ; un agent d~amélioration et un procédé d~amélioration pour une condition dépressive ; une composition pharmaceutique ; et un nécessaire de réactif.

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