G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01)
Patent
CA 2742769
The present invention relates to a method for the diagnosis of tumoural conditions and/ or of the corresponding state of advance, wherein a specimen of an organic fluid taken from the patient and having a high probability of containing at least one circulating tumour cell (CTC) or a disseminated tumour cell (CTD) is enriched in a population of CTCs or CTDs. According to the invention, at least one type of CTCs or CTDs is isolated by selecting individually single cells in a microfluidic device so as to constitute a diagnostic specimen having a purity of at least 90%. On the specimen thus obtained there is subsequently per-formed a molecular analysis such as to highlight a characteristic thereof suited to enabling diagnosis.
La présente invention a pour objet un procédé pour le diagnostic détats tumoraux et/ou dun état davancement correspondant, un échantillon dun liquide organique prélevé chez le patient et présentant une forte probabilité de contenir au moins une cellule tumorale circulante (CTC) ou une cellule tumorale disséminée (CTD) étant enrichi dans une population de CTC ou de CTD. Conformément à linvention, au moins un type de CTC ou de CTD est isolé par la sélection individuelle de cellules simples dans un dispositif microfluidique de sorte à constituer un échantillon de diagnostic ayant une pureté dau moins 90 %. Sur léchantillon ainsi obtenu, on réalise par la suite une analyse moléculaire de sorte à souligner une caractéristique de léchantillon permettant le diagnostic.
Giorgini Giuseppe
Manaresi Nicolo
Medoro Gianni
Gowling Lafleur Henderson Llp
Silicon Biosystems S.p.a.
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