C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2703060
The present invention relates to a method for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, "thumb," "finger," and/or "palm" domain of telomerase and testing the compound for its ability to modulate the activity of telomerase.
L'invention concerne un procédé permettant d'identifier des composés modulant l'activité télomérase. Les composés selon l'invention sont identifiés par élaboration ou criblage d'un composé se liant à au moins un résidu d'acide aminé du TRBD, le domaine 'pouce', 'doigt' et/ou 'paume' de télomérase. La capacité de ce composé à moduler l'activité télomérase est ensuite testée.
Borden Ladner Gervais Llp
The Wistar Institute
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