G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2564767
The invention concerns a method for identifying a ligand capable of selectively modulating a functional cascade involving a target, and uses thereof for high-throughput screening of molecules of interest, in particular therapeutic (medicine). Said method comprises at least the following steps: a) identifying an antibody or an antibody fragment comprising at least one of the variable domains of an immunoglobulin chain, capable of binding to said target and modulating said functional cascade involving said target; b) screening from a bank of molecules, ligands modulating the bond between said target and the antibody or antibody fragment identified in a); and c) identifying among said modulating ligands obtained in b), those capable of modulating said functional cascade.
Procédé d'identification d'un ligand capable de moduler sélectivement une cascade fonctionnelle impliquant une molécule-cible ou cible, ainsi que ses applications pour le criblage à haut-débit de molécules d'intérêt, notamment thérapeutique (médicament). Ledit procédé comprend au moins les étapes suivantes : a) l'identification d'un anticorps ou d'un fragment d'anticorps comprenant au moins l'un des domaines variables d'une chaîne d'immunoglobuline, capable de se lier à ladite cible et de moduler ladite cascade fonctionnelle impliquant ladite cible, b) le criblage à partir d'une banque de molécules, des ligands modulateurs de la liaison entre ladite cible et l'anticorps ou le fragment d'anticorps identifié en a) , et c) l'identification à partir des ligands modulateurs obtenus en b), de ceux capables de moduler ladite cascade fonctionnelle.
Dariavach Piona
Martineau Pierre
Centre National de La Recherche Scientifique
Robic
Universite de Montpellier I.
Universite de Montpellier II
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