A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/145 (2006.01) A61P 3/10 (2006.01) C12Q 1/48 (2006.01) G01N 33/66 (2006.01)
Patent
CA 2399889
The present invention relates to a method for identifying an agent useful for the treatment or prevention of a medical condition related to reduced cellular uptake of glucose, said method comprising the steps of: (i) identifying a target polypeptide interacting with the compound U0126 (1,4-diamino-2,3- dicyano-1,4-bis[2-aminophenylthio]butadiene); (ii) contacting a candidate agent with the said target polypeptide; and (iii) determining whether said candidate agent modulates the biological activities of the said target polypeptide, such modulation being indicative for an agent useful for the treatment or prevention of a medical condition related to reduced cellular uptake of glucose.
Cette invention se rapporte à un procédé permettant d'identifier un agent servant au traitement ou à la prévention d'un état médical associé à une absorption cellulaire réduite de glucose, ce procédé consistant: (i) à identifier un polypeptide cible interagissant avec le composé U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophénylthio]butadiène); (ii) à mettre en contact un agent candidat avec ce polypeptide cible; et (iii) à déterminer si cet agent candidat module les activités biologiques du polypeptide cible, une telle modulation indiquant la présence d'un agent servant au traitement ou à la prévention d'un état médical associé à une absorption cellulaire réduite de glucose.
Biovitrum Ab
Gowling Lafleur Henderson Llp
LandOfFree
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