C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61P 3/06 (2006.01)
Patent
CA 2437434
The invention concerns methods and compounds capable of modulating reverse cholesterol transport in a mammal and screening methods for selecting, identifying and/or characterising compounds capable of modulating reverse cholesterol transport. The invention also concerns cells, vectors and genetic constructs used for implementing said methods, and pharmaceutical compositions for treating atherosclerosis. The inventive methods are based on the use of FXR response elements derived from the apolipoprotein Al gene promoter.
La présente invention concerne des méthodes et composés susceptibles de moduler le transport inverse du cholestérol chez un mammifère ainsi que des méthodes de criblage permettant de sélectionner, d'identifier et/ou de caractériser des composés capables de moduler le transport inverse du cholestérol. Elle concerne également des cellules, vecteurs et constructions génétiques utilisables pour la mise en oeuvre de ces méthodes, ainsi que des compositions pharmaceutiques destinées au traitement de l'athérosclérose. Les méthodes de l'invention sont basées sur l'utilisation d'éléments de réponse à FXR dérivés du promoteur du gène apo AI.
Genfit
Ridout & Maybee Llp
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