C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2542992
A method for identifying analytes which directly or indirectly affect tryptophan hydroxylase isoform 2 (TPH2) expression is described. The method enables glucocorticoid receptor modulators and &bgr;-hydroxysteroid dehydrogenase type 1 (&bgr;-HSD1) inhibitors to be screened for central nervous system penetrance and activity by determining their ability to regulate expression of TPH2. The method is particularly useful for identifying analytes which suppress glucocorticoid disruption of central serotonergic neurotransmission in the brain.
L'invention concerne un procédé d'identification d'analytes qui affectent directement ou indirectement l'expression de tryptophane hydroxylase de l'isoforme 2 (TPH2). Ce procédé permet de trier les modulateurs du récepteur de glucocorticoïde et les inhibiteurs de ?-hydroxystéroïde déshydrogénase de type 1 (?-HSD1) pour la pénétrance et l'activité du système nerveux central par la détermination de leur aptitude à réguler l'expression de TPH2. Ce procédé est particulièrement utile pour identifier les analytes qui suppriment l'interruption du glucocorticoïde de la neurotransmission sérotonergique centrale dans le cerveau.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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