C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) A01N 61/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2308582
The present invention relates to a method of identifying one or more secondary drug targets and their use in the identification of drug or drug candidates, particularly for the treatment of cancer. The yeast-based synthetic lethal screens were used to functionally identify and validate new gene targets to kill tumor cells with defects in cell cycle checkpoints and damage response pathways. These newly identified gene targets can be used to develop new cancer chemotherapeutics.
La présente invention, qui concerne un procédé permettant d'identifier une ou plusieurs cibles secondaires de médicaments, concerne également leur utilisation pour l'identification de médicaments ou de candidats médicaments, particulièrement pour le traitement du cancer. En l'occurrence, on a utilisé des cribles létaux synthétiques à base de levure pour identifier et valider de nouveaux gènes cibles de façon à tuer des cellules tumorales dont les jalons du cycle cellulaire sont défectueux ou dont les chemins de réaction sont endommagés. Les gènes cibles ainsi identifiés se prêtent à la mise au point de nouveaux agents chimiothérapiques anticancéreux.
Friend Stephen
Hartwell Leland
Fred Hutchinson Cancer Research Center
Robic
LandOfFree
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