Method for identifying genes involved in cell proliferation

A - Human Necessities – 01 – K

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A01K 67/00 (2006.01) C12N 15/01 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2433739

The present invention provides fish system as a powerful forward genetic tool to directly identify a number of novel genes involved in cell proliferation in vertebrates without the time consuming and costly maintenance of animals. The invention provides a tool to identify functional characteristics of a protein without prior knowledge of the gene sequence. After identification of the mutant gene in the fish system, the nucleic acid sequence of the gene can be used for identifying a homologue of the gene in another species, for example, in humans.

La présente invention se rapporte à un système à base de poisson utilisé en tant qu'outil génétique perfectionné et puissant permettant d'identifier directement plusieurs nouveaux gènes impliqués dans la prolifération cellulaire chez les vertébrés sans entretien long et coûteux d'animaux. L'invention se rapporte à un outil permettant d'identifier des caractéristiques fonctionnelles d'une protéine sans connaissance préalable de la séquence génique. Après identification du gène mutant dans le système à base de poisson, la séquence d'acide nucléique du gène peut être utilisée pour identifier un homologue du gène dans d'autres espèces, par exemple chez les humains.

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