Method for identifying genes involved in trail-induced...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/113 (2010.01) C12N 5/07 (2010.01) A61K 31/713 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2745775

The invention relates to methods for identifying genes involved in TRAIL- induced apoptosis, to inhibitors of the expression of genes inducing resistance of cells to TRAIL-induced apoptosis and to activators of the expression of a gene sensitizing cells to TRAIL-induced apoptosis. The invention also relates to methods for sensitizing cells to TRAIL-induced apoptosis, methods for treating hyperproliferative diseases, methods for determining the responsiveness of a subject suffering from a hyperproliferative disease to TRAIL, to pharmaceutical compositions comprising products capable of sensitizing cells to TRAIL-induced apoptosis, and to methods for determining the prognosis of a subject suffering from a hyperproliferative disease.

La présente invention concerne des procédés d'identification de gènes impliqués dans l'apoptose induite par TRAIL, des inhibiteurs de l'expression de gènes conférant aux cellules la résistance à l'apoptose induite par TRAIL et des activateurs de l'expression d'un gène sensibilisant les cellules à l'apoptose induite par TRAIL. L'invention concerne également des procédés de sensibilisation des cellules à l'apoptose induite par TRAIL, des procédés de traitement de maladies hyperprolifératives, et des procédés de détermination de la réactivité à TRAIL d'un sujet souffrant d'une maladie hyperproliférative, des compositions pharmaceutiques comprenant des produits capables de sensibiliser les cellules à l'apoptose induite par TRAIL, et des procédés de détermination du pronostic d'un sujet souffrant d'une maladie hyperproliférative.

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