G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/569 (2006.01)
Patent
CA 2717142
The invention concerns the generation of a three dimensional model of the six helix bundle (6HB) complexed with an inhibitor and the use of that model to identify, screen and/or develop inhibitors against viruses that use a class I fusion protein. Such inhibitors of viruses that use a class I fusion protein may be effective for treating, for example, respiratory infections by Respiratory Syncytial Virus (RSV).
La présente invention concerne la production dun modèle en trois dimensions du complexe à six hélices (6HB) mélangé à un inhibiteur et lutilisation de ce modèle pour identifier, dépister et/ou mettre au point des inhibiteurs viraux utilisant une protéine de fusion de classe I. Ces inhibiteurs viraux utilisant une protéine de fusion de classe I peuvent être efficaces pour le traitement, notamment, dinfections respiratoires dues au virus respiratoire syncytial (VRS).
Arnoult Eric Pierre Alexandre
Bonfanti Jean-Francois
de Bondt Hendrik Leon Augusta Jozef
Roymans Dirk Andre Emmy
Van Vlijmen Herman
Gowling Lafleur Henderson Llp
Tibotec Pharmaceuticals
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