Method for identifying inhibitors of g protein coupled...

Details Method for identifying inhibitors of g protein coupled... Method for identifying inhibitors of g protein coupled...

G - Physics

01

N

G01N 33/566 (2006.01) A61K 45/00 (2006.01) C07K 1/04 (2006.01) C07K 7/00 (2006.01) C07K 7/04 (2006.01) C12N 15/11 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2473979

This invention relates to methods for identifying peptides and other compounds which block G protein coupled receptor mediated signaling with high affinity and specificity. Assays developed in conjunction with these methods also are disclosed.

La présente invention concerne des procédés d'identification de peptides et autres composés qui bloque la signalisation provoquée par le récepteur complexé à la protéine G présentant une affinité et une spécificité élevées. L'invention concerne également des bioanalyses réalisées en association avec lesdits procédés. FIG. 1 : 1 LIAISON DU RECEPTEUR COMPLEXE A LA PROTEINE G A LA CUPULE 2 AJOUT DE BIBLIOTHEQUE DE PEPTIDES 3, 5 PROTEINE DE FUSION DE PEPTIDE AU C-TERMINAL DE LacI

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