Method for identifying ligands

Details Method for identifying ligands Method for identifying ligands

G - Physics

01

N

G01N 24/08 (2006.01) G06F 19/16 (2011.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2653959

The present invention provides a process of designing compounds which bind to a specific target molecule. The process includes the steps of a) identifying a first ligand to the target molecule using two-dimensional 15N/1H NMR correlation spectroscopy; b) identifying a second ligand to the target molecule using two-dimensional 15N/1H NMR correlation spectroscopy; c) forming a ternary complex by binding the first and second ligands to the target molecule; d) determining the three-dimensional structure of the ternary complex and thus the spatial orientation of the first and second ligands on the target molecule; and e) linking the first and second ligands to form the drug, wherein the spatial orientation of step (d) is maintained.

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