G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) G01N 33/53 (2006.01) G01N 33/551 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2522483
A method of identifying a ligand specific for a structural isoform of a protein by the binding of the structural isoform to a ligand on a support, a direct positional transfer of the structural isoform and a control isoform between two or more different solid or semi-solid supports and detection of at least one of the isoforms on each support, thus allowing for subtractive identification techniques to be used to identify the subset of ligands, or a ligand, specific for the structural isoform (Figure 1).
L'invention porte sur un procédé d'identification d'un ligand spécifique pour une isoforme structurale d'une protéine par liaison de l'isoforme structurale à un ligand sur un support, par transfert de position direct de l'isoforme structurale et d'une isoforme de contrôle entre au moins deux supports différents solides ou semi-solides et la détection d'au moins une des isoformes sur chaque support, ce qui permet d'utiliser des techniques d'identification soustractives pour identifier le sous-ensemble de ligands, ou un ligand, spécifique de l'isoforme structurale.
Cervenakova Larisa
Gheorghiu Liliana
Hammond David J.
Lathrop Julia T.
Yakovleva Oksana
Mbm Intellectual Property Law Llp
Pathogen Removal And Diagnostic Technologies Inc.
The American National Red Cross
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