Method for identifying maxi-k channel blockers for use in...

Details Method for identifying maxi-k channel blockers for use in... Method for identifying maxi-k channel blockers for use in...

G - Physics

01

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G01N 33/566 (2006.01) A61K 31/165 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) C07C 235/60 (2006.01) C07C 271/34 (2006.01) C07C 327/32 (2006.01) C07D 209/28 (2006.01) C07D 307/78 (2006.01)

Patent

CA 2436744

This invention relates to a method for identifying maxi-K channel blockers comprising using HEK-293 cells that have been stably transfected with both alpha and beta l subunits of the maxi-K channel and incubated with potassium channel blockers that selectively eliminate the endogenous conductances of the HEK-293 cells. Maxi-K channels are important for controlling a number of physiological processes. They play a role in the regulation of aqueous humor dynamics in the eye. Maxi-K channel blockers are known to reduce intraocular pressure.

L'invention concerne un procédé relatif à l'identification d'inhibiteurs de canaux maxi-K. Ce procédé consiste à utiliser des cellules HEK-293 ayant subi une transfection stable par des sous-unités alpha et bêta-1 du canal maxi-X et une incubation avec des inhibiteurs de canaux potassiques qui éliminent sélectivement les conductances endogènes des cellules HEK-293. Les canaux maxi-K ont une fonction importante pour le contrôle d'un certain nombre de processus physiologiques. Ils interviennent dans la régulation de la dynamique propre à l'humeur aqueuse de l'oeil. On sait par ailleurs que les inhibiteurs de canaux maxi-K réduisent la pression intra-oculaire.

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