Method for identifying mhc alleles in dogs

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2630472

A method for identifying one or more MHC alleles present in a dog, the method comprising: (a) determining the nucleotide present at the or each polymorphic position specified for the one or more MHC alleles in any one of Tables 4 to 6 or determining the nucleotide (s) present at a polymorphic position (s) in linkage disequilibrium with one or more polymorphic positions specified in Tables 4 to 6; and (b) identifying therefrom the presence or absence of one or more MHC alleles in the dog. Based on the comparison between alleles, it was possible to specify a minimum number of SMP positions that need to be determined in order to identify a particular allele (Table 4 to 6) .

L'invention concerne un procédé pour identifier un ou plusieurs allèles du CMH présents chez un chien, ledit procédé consistant : (a) à déterminer le nucléotide présent à la ou à chaque position polymorphe spécifiée pour lesdits un ou plusieurs allèles du CMH dans un des tableaux 4 à 6 ou à déterminer le(s) nucléotide(s) présent(s) à une position polymorphe en déséquilibre de liaison avec une ou plusieurs positions polymorphes spécifiées dans les tableaux 4 à 6 et (b) à identifier ainsi la présence ou l'absence d'un ou de plusieurs allèles du CMH chez le chien.

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