Method for identifying modulators of clk-1 and ubif activity

G - Physics – 01 – N

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G01N 33/50 (2006.01) C12N 15/00 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2523770

The present invention provides methods for screening modulators of 2 polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone (DMQ) hydroxylation activity, inhibitors and activators of the activity, and methods of using such compounds. More particularly, this invention relates to modulators of and UbiF and CLK-1 enzyme activity and methods of identifying same.

La présente invention se rapporte à des procédés de criblage de modulateurs de l'activité d'hydroxylation de la 2-polyprényl-3-méthyl-6-méthoxy-1,4-benzoquinone (DMQ), d'inhibiteurs et d'activateurs de ladite activité, ainsi qu'à des procédés d'utilisation de tels composés. Plus précisément, l'invention a trait à des modulateurs de l'activité enzymatique de UbiF et CLK-1, ainsi qu'à des procédés d'identification desdits modulateurs.

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