Method for identifying modulators of g protein coupled...

Details Method for identifying modulators of g protein coupled... Method for identifying modulators of g protein coupled...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/08 (2006.01) A61K 45/00 (2006.01) C07K 2/00 (2006.01) C07K 7/06 (2006.01) C07K 16/00 (2006.01) C40B 30/04 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2522076

This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these methods also are disclosed.

La présente invention a trait à des procédés pour l'identification de peptides et d'autres composés qui bloquent ou activent la signalisation induite par le récepteur couplé à une protéine G avec une affinité et une spécificité élevée et/ou qui stabilisent un conformère d'un récepteur couplé à une protéine G. L'invention a également trait à des analyses biologiques, des procédés de traitement et d'autres procédés développés conjointement avec ces procédés.

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