C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01N 37/18 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2613082
Compositions and methods for identifying modulators of RUFY2 are described. The methods are particularly useful for identifying analytes that antagonize RUFY2~s effect on processing of amyloid precursor protein to A.beta. peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.
L'invention concerne des compositions et des méthodes permettant d'identifier des modulateurs de RUFY2. Ces méthodes sont particulièrement utiles pour identifier des analytes qui antagonisent l'effet de RUFY2 sur la maturation de la protéine précurseur amyloïde du peptide ß-amyloïde et sont donc utiles pour identifier des analytes pouvant être utilisés dans le traitement de la maladie d'Alzheimer.
Majercak John M.
Ray William J.
Stone David J.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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