Method for identifying non-essential genes of the human...

Details Method for identifying non-essential genes of the human... Method for identifying non-essential genes of the human...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) C07K 14/045 (2006.01) C07K 16/08 (2006.01) C12N 9/24 (2006.01) C12N 15/38 (2006.01) C12N 15/869 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2073085

31,617-00 METHODS FOR IDENTIFYING NON-ESSENTIAL GENES OF THE HUMAN CYTOMEGALOVIRUS GENOME AND FOR SCREENING FOR INHIBITORS OF HUMAN CYTOMEGALOVIRUS Abstract of the Disclosure This invention relates to a method for identifying non- essential genes of the human cytomegalovirus (HCMV) genome through the insertion of a .beta.-glucuronidase marker gene into a specified HCMV gene, such that, if the product of the HCMV gene is not expressed, the gene is identified as non- essential for replication of HCMV. This invention also relates to a method of screening for compounds which inhibit HCMV by the insertion of the .beta.-glucuronidase marker gene into a HCMV gene, such that the enzyme marker is expressed and cleaves a conjugate chemical substrate in an assay system to yield a detectable fluorescing product or to result in a color change. This invention further provides the gene responsible in HCMV early cytopathic effect.

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