Method for identifying nucleic acids encoding c-fos promoter...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/37 (2006.01) C12N 15/67 (2006.01) C12N 15/69 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2194361

Materials and methods are described for identifying signal transducing molecules which activate promoters, such as the human c-fos proto-oncogene promoter, as well as antagonists of such molecules. Also described are human c- fos promoter activating proteins, and in particular novel proteins, designated CROC-1 protein and CROC-4 protein, nucleic acids encoding said proteins, and mammalian cells transfected with vectors containing such nucleic acids.

Cette invention se rapporte à des substances et à des procédés qui servent à identifier des molécules transductrices de signal qui activent des promoteurs, tels que le promoteur de proto-oncogène c-fos humain, ainsi que des antagonistes de ces molécules. Cette invention décrit également des protéines activant ce promoteur c-fos humain, et en particulier de nouvelles protéines, appelées protéine CROC-1 et protéine CROC-4, des acides nucléiques codant ces protéines, ainsi que des cellules de mammifères transfectées au moyen de vecteurs contenant de tels acides nucléiques.

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