Method for identifying pde5-modulators

Details Method for identifying pde5-modulators Method for identifying pde5-modulators

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) C12N 5/10 (2006.01) C12N 15/60 (2006.01) C12N 15/62 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2590553

The invention relates to a novel polypeptide containing the GAFA-domain and GAFB-domain of a human phosphodiesterase 5 (PDE5) and the catalytic domain of an adenylate cyclase, and to the use of this polypeptide in a method for identifying PDE5-modulators.

L'invention concerne un nouveau polypeptide contenant les domaines <SB>GAFA</SB> et les domaines GAF<SB>B</SB> d'une phosphodiestérase 5 humaine (PDE%) et les domaines catalytiques d'une adénylate-cyclase, ainsi que l'utilisation de ce polypeptide dans une méthode d'identification de modulateurs de PDE5.

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