G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2204863
The present invention provides a novel method for the identification of antigens which may be useful for inducing neutralizing antibodies. The method is based on the use of antigens as solid phase capture reagents to bind to a population of antibodies from a subject having an infection and high neutralizing serum titers through the period of natural infection. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies.
Cette invention propose une nouvelle méthode pour l'identification d'antigènes pouvant être utiles à la production d'anticorps neutralisants. Cette méthode est fondée sur l'utilisation d'antigènes en tant que réactifs de capture lors de la phase solide, lesquels doivent se lier à une population d'anticorps provenant d'un sujet atteint d'une infection et possédant des titres de sérum fortement neutralisants pendant la phase d'infection naturelle. Cette méthode convient particulièrement au triage de bibliothèques d'anticorps clonés, tels que des anticorps combinatoires à caractère bactériophage.
Barbas Carlos F. III
Burton Dennis R.
Parren Paul W. H. I.
Williamson Anthony R.
Fetherstonhaugh & Co.
The Scripps Research Institute
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