Method for identifying risk of melanoma and treatments thereof

Details Method for identifying risk of melanoma and treatments thereof Method for identifying risk of melanoma and treatments thereof

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12N 9/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2504903

Provided herein are methods for identifying risk of melanoma in a subject and/or subjects at risk of melanoma, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating melanoma, therapeutic methods for treating melanoma in a subject and compositions comprising one or more melanoma cells and one or more CDK10, FPGT, PCLO or REPS2 directed agents. These embodiments are based upon an analysis of polymorphic variations in a CDK10, FPGT, PCLO or REPS2 nucleic acid, exemplified by nucleotide sequences of SEQ ID NO: 1, 2, 3 or 4.

L'invention concerne des méthodes d'identification du risque de mélanome chez un sujet et/ou des sujets présentant un risque de mélanome, des réactifs et des kits pour la réalisation des méthodes, des méthodes d'identification de thérapeutiques candidates dans le traitement de mélanome, des méthodes thérapeutiques de traitement de mélanome chez un sujet et des compositions contenant au moins une cellule de mélanome et au moins un agent dirigé <I>CDK10, FPGT, PCLO</I> ou <I>REPS2</I>. Ces modes de réalisation reposent sur une analyse des variations polymorphes dans un acide nucléique <I>CDK10, FPGT, PCLO</I> ou <I>REPS2</I> exemplifié par des séquences de nucléotides de SEQ ID NO: 1, 2, 3 ou 4.

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