A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/54 (2006.01) A61L 27/04 (2006.01) A61L 27/28 (2006.01) A61L 27/34 (2006.01) A61L 31/02 (2006.01) A61L 31/08 (2006.01) A61L 31/10 (2006.01) C23C 22/24 (2006.01)
Patent
CA 2311445
A mediator molecule is immobilized on the surface of a metallic or ceramic implant material. An anchor molecule such as a dialdehyde having a functional group that covalently binds the mediator molecule is covalently bound to the surface, and the mediator molecule is coupled to the functional group of the anchor molecule. The implant material may be composed of titanium, titanium alloy, aluminum, stainless steel or hydroxylapatite. Oxide units on the surface of the implant material can be increased preferably by treating with hot chromic-sulphuric acid for 0.5 to 3 hours at a temperature between 100 to 250° C. prior to binding the anchor molecule. Also, prior to binding the anchor molecule, the surface of the implant material can be activated by reacting with a silane derivative. Mediator molecules include BMP protein, ubiquitin and antibiotics, and the implant material may be an artificial joint or coronary vessel support such as a stent
L'invention concerne un procédé pour immobiliser des molécules médiatrices sur des surfaces de matériaux métalliques ou céramiques utilisés pour des implants tels que des articulations artificielles ou des extenseurs. L'invention concerne également des implants produits selon ledit procédé.
Blake Cassels & Graydon Llp
Jennissen Herbert Peter
Morphoplant Gmbh
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