A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
167/327
A61L 27/00 (2006.01) A61F 2/02 (2006.01) A61L 27/38 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2031532
The present invention is a method and means whereby large volumes of cells having a desired function are attached to, and, optionally, proliferated, on a biocompatible degradable, non-degradable or combination degradable-non-degradable scaf- folding and transferred with mininal trauma and blood loss into a patient at a site appropriate for attachment, growth and func- tion to produce a functional organ equivalent in the absence of vascularization of the implanted cell mass. In the preferred em- bodiment multiple cell-matrix structures are implanted between folds of the mesentery. The method is particularly well suited for growth of endocrine structures, including liver, pancreas, and adrenal gland, as well as other tissues. The preferred material for forming the matrix or support structure is a biodegradable artificial polymer. Materials such as angiogenesis factors can be incor- porated into degradable matrices for use in preparing the implantation sites prior to, or at the time of, implanting the calls. The function and viability of the attached cells can also be manipulated by treatment or coatiing of the matrix structure to increase the number of attachment sites.
Griffith-Cima Linda
Johnson Lynt
Langer Robert S.
Vacanti Joseph P.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Children's Hospital
Children's Medical Center Corporation
Massachusetts Institute Of Technology
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