Method for improved diagnosis of dysplasias

Details Method for improved diagnosis of dysplasias Method for improved diagnosis of dysplasias

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2496465

The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

L'invention concerne une méthode permettant d'établir un diagnostic amélioré de dysplasies fondée sur une détection simultanée de produits de gènes INK4a et d'au moins un marqueur de prolifération cellulaire. L'invention concerne en particulier une méthode permettant de discriminer des cellules dysplastiques surexprimant des produits de gènes INK4a de cellules surexprimant des produits de gènes INK4a non dysplastiques par détection d'un marqueur apte à caractériser les propriétés de prolifération de la cellule respective. La caractérisation des propriétés de prolifération peut comprendre la détection d'un marqueur ou d'un ensemble de marqueurs caractéristiques de prolifération cellulaire active et/ou d'un marqueur ou d'un ensemble de marqueurs caractéristiques de prolifération cellulaire retardée ou interrompue. La méthode de l'invention permet ainsi d'établir un diagnostic spécifique de dysplasies dans des spécimens histologiques et cytologiques.

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