C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) C07K 16/00 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2596925
It is intended to provide a method for improving a property such as the expression level or stability of an antibody. A method for obtaining an antibody whose expression level and/or stability is increased by improving a human antibody or a humanized antibody characterized by replacing at least any one of amino acids at positions 8, 12, 15 and 18 (according to the Kabat numbering) in the light chain variable region (hereinafter referred to as VL chain) of human antibody or humanized antibody with another amino acid other than proline or cysteine and a human antibody, a humanized antibody, or a fragment of human antibody or humanized antibody whose expression level and/or stability is increased obtained by the method.
La présente invention concerne un procédé permettant d~améliorer une propriété telle que le niveau d~expression ou la stabilité d~un anticorps. Elle concerne également un procédé permettant d~obtenir un anticorps dont le niveau d~expression et/ou la stabilité est accru grâce à l~amélioration d~un anticorps humain ou d~un anticorps humanisé caractérisé en ce qu~il remplace au moins l~un quelconque des acides aminés en position 8, 12, 15 et 18 (selon la numérotation de Kabat) dans la région variable d~une chaîne légère (désignée ci-après par chaîne VL) de l~anticorps humain ou de l~anticorps humanisé par un acide aminé différent de la proline ou de la cystéine, et permettant d~obtenir un anticorps humain, un anticorps humanisé ou un fragment d~anticorps humain ou d~anticorps humanisé dont le niveau d~expression et/ou la stabilité est accru grâce au procédé.
Nakashima Toshihiro
Torikai Masaharu
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Kirby Eades Gale Baker
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