Method for improving cell permeability to foreign particles

Details Method for improving cell permeability to foreign particles Method for improving cell permeability to foreign particles

A - Human Necessities

61

K

A61K 31/155 (2006.01) A01N 37/52 (2006.01)

Patent

CA 2641599

The present invention provides a method for allowing foreign particles to penetrate, very efficiently, the cell wall, cell membrane, organelle membrane and/or nuclear membrane of a cell and hybridizing or binding to the complimentary target in the cell. The cells may be from a culture or from specimens obtained from a patient. The foreign particle can be a probe consisting of, for example, either individually or in any combination of two or more of the following: DNA, RNA, peptide nucleic acids (PNA), glycopeptides, lipopeptides, glycolipids or prions. The target is a cell, a cell component or, preferably, a pathogen or pathogen component. The pathogen can be, for example, bacteria, fungi, yeast or viruses.

La présente invention concerne un procédé permettant aux particules étrangères de pénétrer, de manière très efficace, la paroi cellulaire, la membrane cellulaire, la membrane organelle et/ou la membrane nucléaire d~une cellule et d'obtenir une hybridation ou une liaison avec la cible complémentaire dans la cellule. Les cellules peuvent provenir d~une culture ou bien de spécimens obtenus d~un patient. La particule étrangère peut être une sonde consistant en, par exemple, individuellement ou en combinaison de deux des éléments suivants ou davantage : ADN, ARN, acides nucléiques peptides (ANP), glycopeptides, lipopeptides, glycolipides ou prions. La cible est une cellule, une composante de cellule ou de préférence un pathogène ou une composante pathogène. Le pathogène peut être par exemple une bactérie, un champignon, de la levure ou des virus.

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