Method for improving pharmacokinetics of protease inhibitors...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61K 31/135 (2006.01) A61K 31/4196 (2006.01) A61K 31/513 (2006.01) A61K 31/5375 (2006.01) A61K 31/661 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2606025

The present invention provides methods for improving the pharmacokinetics of protease inhibitors and protease inhibitor precursors and pharmaceutical composition comprising protease inhibitors or protease inhibitor precursors of formula I and a cytochrome P450 monooxigenase inhibitor; Formula (I) when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for example, (HO)2P(O)-, (NaO)2P(O)- , alkyl- CO- or cycloalkyl-CO-, wherein X may be, for example, F, CI, and Br, and wherein R2 and R3 are as defined herein.

La présente invention concerne des procédés pour améliorer la pharmacocinétique d'inhibiteurs de protéase et de précurseurs d'inhibiteurs de protéase et une composition pharmaceutique comprenant des inhibiteurs de protéase ou des précurseurs d'inhibiteurs de protéase selon la formule I et un inhibiteur de la monooxygénase du cytochrome P450 ; Formule (I) dans laquelle le composé comprend un groupe amino, des sels d'ammonium pharmaceutiquement acceptables de celui-ci, où R1 peut être, par exemple (HO)2P(O)-, (NaO)2P(O)-, un alkyle- CO- ou un cycloalkyle-CO-, où X peut être, par exemple, F, CI, et Br, et où R2 et R3 sont tels que définis ici.

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