A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/12 (2006.01) A61K 31/198 (2006.01) A61K 38/06 (2006.01) A61P 39/06 (2006.01)
Patent
CA 2714200
Provision of a method of improving preservation stability of glutathione in a solid composition containing glutathione and arginine, or a solid composition containing glutathione and arginine, which shows improved preservation stability of glutathione. In the production of a solid composition containing glutathione and arginine, glutathione and arginine are made to be coexistent with an organic acid. Examples of the organic acid include citric acid, tartaric acid, ascorbic acid, malic acid, malonic acid, succinic acid, fumaric acid, maleic acid and the like. The amount of the organic acid to be coexistent with glutathione and arginine is generally 0.1 - 2 parts by weight relative to 1 part by weight of arginine.
L'invention porte sur un procédé pour améliorer la stabilité au stockage du glutathion dans une composition solide contenant du glutathion et de l'arginine. L'invention porte également sur une composition solide contenant du glutathion et de l'arginine, qui a une stabilité au stockage améliorée du glutathion. De façon spécifique, lorsqu'une composition solide contenant du glutathion et de l'arginine est obtenue, un acide organique est amené à coexister avec le glutathion et l'arginine. Des exemples de l'acide organique peuvent comprendre l'acide citrique, l'acide tartrique, l'acide ascorbique, l'acide malique, l'acide malonique, l'acide succinique, l'acide fumarique et l'acide maléique. La quantité de l'acide organique devant coexister avec le glutathion et l'arginine est habituellement de 0,1 à 2 parties en poids pour 1 partie en poids d'arginine.
Kayahashi Shun
Sakai Yasushi
Fetherstonhaugh & Co.
Kyowa Hakko Bio Co. Ltd.
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