Method for improving the biocompatibility of solid surfaces

Details Method for improving the biocompatibility of solid surfaces Method for improving the biocompatibility of solid surfaces

C - Chemistry, Metallurgy

07

K

C07K 17/06 (2006.01) A61L 27/00 (2006.01) A61L 29/00 (2006.01) A61L 31/00 (2006.01) A61L 33/00 (2006.01) C08B 37/10 (2006.01)

Patent

CA 2112619

ABSTRACT A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.

Affiliated with

Also associated with

Rating

Method for improving the biocompatibility of solid surfaces does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for improving the biocompatibility of solid surfaces, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for improving the biocompatibility of solid surfaces will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1545990