A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A23P 1/00 (2006.01)
Patent
CA 2734187
The present invention relates to a method of making a film composition with an improved uniformity of active composition The invention includes a method including the steps of forming a flowable film composition comprising an edible water-soluble polymer, a polar solvent and a particulate active suspended therein, where the ratio of solids to liquids is at least about 95 to about 5 and where the composition comp.pi.rses a mixture having compositional uniformity per unit volume, directing the flowable film composition to a transfer trough, the transfer trough including a first rotating roller and a movable transfer substrate upon which to form the film, and maintaining uniformity of the flowable film composition dunng the residence time in the trough by maintaining the rate of composition ente.pi.ng the transfer trough and the level of the flowable film composition in the transfer trough at a substantially constant level
La présente invention concerne un procédé de fabrication d'une composition de film ayant une uniformité de composition active améliorée. L'invention comprend un procédé qui consiste à former une composition de film pouvant s'écouler comportant un polymère comestible soluble dans l'eau, un solvant polaire et une particule active suspendue dans celle-ci, le rapport de solide sur liquide étant au moins d'environ 95 à environ 5 et la composition comportant un mélange ayant une uniformité de composition par volume unitaire, à diriger la composition de film pouvant s'écouler vers une goulotte de transfert, la goulotte de transfert comprenant un premier rouleau rotatif et un substrat de transfert mobile sur lequel former le film, et à maintenir l'uniformité de la composition de film pouvant s'écouler pendant le temps de séjour dans la goulotte en maintenant le débit de composition entrant dans la goulotte de transfert et le niveau de composition de film pouvant s'écouler dans la goulotte de transfert à un niveau sensiblement constant.
Dailey Patrick
Hariharan Madhusudan
Myers Garry
Sanghvi Pradeep
Szopinski Alex
Monosol Rx Llc
Piasetzki Nenniger Kvas Llp
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