A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/139
A61K 39/00 (2006.01) C12N 5/16 (2006.01) C12N 5/20 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)
Patent
CA 1340099
A method for the removal of, for in vitro immunisation, undesired cells from human lymphocyte containing cell populations is disclosed. For the method, use is made of lysosomotropic agents which are caused to act in vitro on human lymphocyte containing cell populations. Also disclosed is a method in the in vitro immunisation of lymphocytes for use in the production of human monoclonal antibodies. In this method, lysosomotropic agents are caused to act in vitro on human lymphocyte containing cell populations for removing cell populations having a negative effect on the in vitro immunisation, whereupon the lymphocytes are in vitro immunised antigen-specifically and immortalised. Finally, a kit for in vitro immunisation of lymphocytes for use in the production of human monoclonal antibodies is disclosed. The kit comprises as active constituents a container containing lymphokines and a container containing lysosomotropic agents.
546024
Borrebaeck Carl
Danielsson Lena
Moller Susanna
Bioinvent International Ab
Fetherstonhaugh & Co.
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