Method for in vitro selection of 2'-substituted nucleic acids

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2506748

Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. The aptamers produced by the methods of the invention have increased stability and half life.

L'invention concerne des matières et des méthodes de production de substances thérapeutiques aptamères dont la séquence incorpore des triphosphates nucléotidiques modifiés. Les aptamères produits par les méthodes de l'invention présentent une stabilité et une demi-vie accrues.

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