Method for increasing hdl cholesterol level

Details Method for increasing hdl cholesterol level Method for increasing hdl cholesterol level

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/45 (2006.01) A61K 39/385 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2223177

The present invention provides a method for increasing HDL cholesterol in a mammal by stimulating an immune response that inhibits the function of CETP. Such an immune response can be induced by immunizing with CETP or fragments of CETP (together termed "CETP Peptides") which contain an epitope capable of stimulating such a response. The peptides can be conjugated to a carrier, such as KLH or ovalbumin, in order to increase immunogenicity. Adjuvants can also be administered.

Ce procédé permet d'accroître le taux de cholestérol des LPHD chez un mammifère en stimulant une réponse immunitaire qui inhibe la fonction de la protéine de transfert du cholestéryl ester (CETP). On peut induire cette réponse immunitaire par immunisation avec la CETP ou certains de ses fragments (collectivement appelés "peptides CETP"), qui contiennent un épitope pouvant stimuler une telle réponse. Ces peptides peuvent être conjugués à un vecteur tel que l'hémocyanine de patelle ou l'ovalbumine, pour accroître l'immunogénicité. On peut aussi administrer des adjuvants.

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