C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/67 (2006.01) C12N 15/81 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2295310
A method is provided whereby genetically altered cells exhibit increased levels of secreted protein, such as to provide increased yields of recombinant proteins. The cells are genetically altered to increase synthesis of ribosome receptors, which induces proliferation of components of the secretory pathway.
L'invention concerne un procédé par lequel des cellules modifiées génétiquement présentent des taux accrus de protéine sécrétée, de façon à fournir des rendements accrus de protéines recombinées. Les cellules sont modifiées génétiquement afin d'accroître la synthèse de récepteurs de ribosomes, ce qui provoque une prolifération de constituants de la voie sécrétoire.
Becker Frank
Meyer David I.
Cassan Maclean
The Regents Of The University Of California
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