Method for increasing the hybridization rate of nucleic acids

Details Method for increasing the hybridization rate of nucleic acids Method for increasing the hybridization rate of nucleic acids

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2409523

The invention provides a method for increasing the hybridization rate of nucleic acids in a nucleic acid assay by labeling nucleic acid molecules with paramagnetic labels and activating a magnetic field inducing rapid migration of the labeled molecules to a solid support, where the labeled molecule hybridizes with its complementary pair. The paramagnetic label may be present on the target nucleic acid or the probe nucleic acid, depending upon whether the target or probe are the immobile phase.

L'invention concerne un procédé permettant d'augmenter le taux d'hybridation des acides nucléiques dans un dosage d'acide nucléique en marquant des molécules d'acide nucléique à l'aide d'étiquettes paramagnétiques et en activant un champ magnétique. Ce champ induit alors une migration rapide des molécules marquées vers un support solide. La molécule marquée s'hybride avec sa paire complémentaire. L'étiquette paramagnétique peut être présente sur l'acide nucléique cible ou l'acide nucléique sonde selon que la cible ou la sonde se trouvent dans la phase immobile.

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