A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/265 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2519458
The invention is directed to a method of increasing the bioavailability of the active form of S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl] 2- methylpropanethioate by administration of a therapeutically effective amount of the drug with food. The invention also provides a kit comprising a pharmaceutical composition comprising a therapeutically effective amount of S- [2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl] 2-methylpropanethioate and a pharmaceutically acceptable carrier, prescribing information, and a container, wherein the prescribing information includes advice to a patient regarding administration of the drug with food to improve bioavailability.
Cette invention se rapporte à un procédé pour accroître la biodisponibilité de la forme active de S-[2-([[1-(2-éthylbutyl)cyclohéxyl]carbonyl]amino)phényl]2-méthylpropanethioate, en administrant une quantité thérapeutiquement efficace de ce médicament avec un aliment. Cette invention concerne également un kit qui comprend une composition pharmaceutique contenant une quantité thérapeutiquement efficace de S-[2-([[1-(2-éthylbutyl)cyclohéxyl]carbonyl]amino)phényl]2-méthylpropanethioate et un excipient pharmaceutiquement acceptable, des informations de prescription et un récipient dans lequel les informations de prescription contiennent des conseils au patient concernant l'administration du médicament avec un aliment en vue d'en améliorer la biodisponibilité.
Ishikawa Tomohiro
Urata Yasuo
Japan Tobacco Inc.
Ridout & Maybee Llp
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