Method for increasing the pool of ngn3+ endocrine progenitor...

Details Method for increasing the pool of ngn3+ endocrine progenitor... Method for increasing the pool of ngn3+ endocrine progenitor...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/39 (2006.01)

Patent

CA 2752267

The present invention discloses a method for increasing the pool of Ngn3+ endocrine progenitor cells obtained from stem cells, by contacting said stem cells with a SUR1/Kir6.2 channel inhibitor. The invention also relates to a method for increasing the mass of pancreatic endocrine cells, in particular of .beta. cells. The invention further concerns a method for treating diabetes.

La présente invention concerne un procédé d'augmentation des fonds de cellules progénitrices endocriniennes Ngn3+ obtenues à partir de cellules souches, par mise en contact desdites cellules souches avec un inhibiteur du canal SUR1/Kir6.2 L'invention concerne également un procédé d'augmentation de la masse de cellules endocriniennes pancréatiques, notamment de cellules ß. L'invention concerne également un procédé de traitement du diabète.

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