A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) C07D 207/09 (2006.01)
Patent
CA 2271724
A method is disclosed for increasing the solubility of clemastine through the use of organic acid or its salts as a solubilizing agent. Particularly useful as solubilizing agents are salts of carboxylic acids, such as fumarate, maleate and citrate. Pharmaceutical compositions containing clemastine, and organic acids or its salts as solubilizing agents, are also disclosed.
La présente invention concerne un procédé permettant d'améliorer la solubilité de la clémastine par l'utilisation d'un solubilisant tel qu'un acide organique ou certains de ses sels. En l'occurrence, les solubilisants qui conviennent le mieux comme sont les acides carboxyliques sous la forme de fumarate, de maléate ou de citrate. L'invention concerne également des compositions à base de clémastine et de solubilisants tels que des acides organiques ou certains de leurs sels.
Behl Charanjit R.
Demeireles Jorge C.
Pimplaskar Harish K.
Romeo Vincent D.
Sileno Anthony P.
Borden Ladner Gervais Llp
Nastech Pharmaceutical Co. Inc.
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