Method for inducing a trif-bias

Details Method for inducing a trif-bias Method for inducing a trif-bias

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 31/7028 (2006.01)

Patent

CA 2748038

The use of a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527.

Emploi d'un aminoalkylglusoaminide 4-phosphate (AGP) choisi, CRX-547, pour induire une réponse biaisée vis-à-vis de TRIF dans un système humain, qui entraîne la diminution de la teneur en cytokines MyD88-dépendantes par rapport aux cytokines MyD88-dépendantes induites par son diastéréoisomère, l'AGP CRX-527.

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