C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/07 (2010.01)
Patent
CA 2755887
The present invention has as its object developing a method that does not involve genomic modification and which yet is capable of inducing cell death in pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, as well as in differentiated cells other than cardiomyocytes derived from pluripotent stem cells, but not in cardiomyocytes. It has been revealed that by establishing a method capable of inducing cell death in cells other than cardiomyocytes in a very efficient manner by adding a substance having no recognized inherent toxicity or cell death inducing action to the culture conditions for pluripotent stem cells and non-cardiomyocytes, the stated problem can be solved without relying upon genomic modification.
L'invention porte sur un procédé qui peut induire la mort cellulaire de cellules souches pluripotentes, telles que des cellules souches embryonnaires, des cellules souches pluripotentes induites et des cellules différentiées autres que des myocytes cardiaques issues de cellules souches pluripotentes, et qui n'induit pas la mort cellulaire de myocytes cardiaques sans utiliser de modification génétique. Par l'addition d'une substance qui n'est pas reconnue comme présentant une toxicité physique ou une activité induisant la mort cellulaire, dans des conditions de culture, d'une cellule souche pluripotente ou d'un myocyte non cardiaque, il devient possible d'établir un procédé pour induire la mort cellulaire de cellules autres que des myocytes cardiaques avec une efficacité extrêmement élevée sans utiliser de modification génétique.
Fukuda Keiichi
Hattori Fumiyuki
Daiichi Sankyo Company Limited
Keio University
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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