Method for inducing cytotoxic t lymphocyte

Details Method for inducing cytotoxic t lymphocyte Method for inducing cytotoxic t lymphocyte

C - Chemistry, Metallurgy

12

N

C12N 5/0783 (2010.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2476143

A method for inducing an antigen-specific cytotoxic T lymphocyte (CTL) which recognizes determinants of disease-related antigens, such as from cancer or tumor cells, viral infections, intracellular bacterial infections, or parasitic infections. Lymphocytes are contacted or co-cultured with a cell line which expresses at least one major histocompatibility (MHC) class I molecules and a co-stimulatory molecule, after or while bringing the cell line into contact with a disease antigenic peptide. Alternatively, the lymphocytes may be contacted with a cell line expressing at least one MHC class I molecules andan accessory molecule and presenting an antigen. The CTLs induced by these methods may be used to treat cancer or infectious diseases. Methods for testing the proliferation potential of a lymphocyte sample using cell lines expressing MHC class I molecules and accessory molecules are also disclosed.

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