C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 38/22 (2006.01) A61K 45/00 (2006.01) A61P 43/00 (2006.01) C12N 5/06 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2360684
It has been found out that prolactin, which is one of the components of fetal bovine serum (FBS), is capable of inducing the expression of C/EBP.beta. gene and PPAR.gamma. gene in multipotential mesenchyme stem cells and thus differentiating these cells into adipocytes. It has been further found out that a compound regulating the differentiation into adipocytes can be screened by using an adipocyte differentiation system with the use of prolactin.
On a constaté que la prolactine, c'est-à-dire l'un des composants du sérum de veau fétal (SVF), pouvait induire l'expression du gène C/EPB.beta. et du gène PPAR.gamma. dans les cellules embryonnaires mésenchymateuses, ce qui permet la différenciation de ces cellules en adipocytes. On a également constaté qu'un composé régulant ladite différenciation pouvait être criblé : il faut pour cela utiliser en combinaison un système de différenciation sous forme d'adipocyte et la prolactine.
Wakao Hiroshi
Wakao Rika
Blake Cassels & Graydon Llp
Helix Research Institute
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