A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/51 (2006.01) C12N 9/88 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2176934
Pharmaceutical compositions for delivering an effective dose to a desired site of a heparinase. These compositions are based on the discovery that heparinase alone can inhibit angiogenesis. The effective dosage is dependent not only on the heparinase, but also on the method and means of delivery, which can be localized or systemic. For example, in some applications, as in the treatment of psoriasis or diabetic retinopathy, the inhibitor is delivered in a topical ophthalmic carrier. In other applications, as in the treatment of solid tumors, the inhibitor is delivered by means of a biodegradable, polymeric implant.
L'invention concerne des compositions pharmaceutiques destinées à apporter une dose efficace d'une héparinase sur un site désiré, et qui sont basées sur la découverte que l'héparinase seule peut inhiber l'angiogenèse. Le dosage efficace dépend non seulement de l'héparinase mais également de la méthode et des moyens d'apport, qui peuvent être par voie localisée ou générale. Par exemple, dans certaines applications, comme dans le traitement du psoriasis ou de la rétinopathie diabétique, on administre l'inhibiteur au moyen d'un exipient ophtalmique topique. Dans d'autres applications, comme dans le traitement de tumeurs solides, on administre l'inhibiteur au moyen d'un implant polymère biodégradable.
Cooney Charles L.
Langer Robert S.
Moses Marsha A.
Nugent Matthew A.
Sasisekharan Ramnath
Bereskin & Parr
Children's Medical Center Corporation
Massachusetts Institute Of Technology
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