A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/00 (2006.01) A61L 27/24 (2006.01) A61L 27/36 (2006.01) A61F 2/00 (2006.01)
Patent
CA 2312376
A method for preparing collagenous biological tissues for use as implantable bioprosthetic material, and articles prepared thereby. The method generally comprises the steps of a) contacting the tissue with an aldehyde fixative to effect cross-linking of the connective tissue protein(s) and subsequently b) contacting the tissue with a polyglycidyl ether. The treatment of the cross-linked tissue with the polyglycidyl ether serves to mitigate the tissue's propensity to undergo calcification following implantation in the body.
Cette invention concerne un procédé de préparation de tissus biologiques collagènes utilisés comme matériaux implantables de bioprothèse ainsi que des articles élaborés selon ce procédé. En règle générale, ledit procédé consiste à: a) mettre le tissu en contact avec un fixateur aldéhyde en vue de l'obtention d'une réticulation de la ou des protéine(s) tissulaire(s) de liaison et b)mettre le tissu en contact avec un éther polyglycidylique. Le traitement du tissu réticulé à l'éther polyglycidylique sert à atténuer la tendance à la calcination du tissu après implantation dans l'organisme.
Dinh Tan Thanh
Lee Catherine Ting
Pfadenhauer Ernest H.
Yang Jun
Baxter International Inc.
Edwards Lifesciences Corporation
Sim & Mcburney
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