Method for inhibiting cell-mediated killing of target cells

Details Method for inhibiting cell-mediated killing of target cells Method for inhibiting cell-mediated killing of target cells

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/55 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/81 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2231804

Disclosed is a method for inhibiting cell-mediated (e.g., CTL-mediated) killing of a mammalian target cell by expressing in the target cell a poxvirus serpin proteinase inhibitor (SPI)-1. If desired, SPI-2 can be expressed in the cell in addition to SPI-1. Cells expressing these proteinase inhibitors are resistant to cell-mediated killing and apoptosis.

L'invention porte sur un procédé inhibant l'élimination à médiation cellulaire (par exemple, par des lymphocytes T cytotoxiques) d'une cellule-cible mamalienne par expression, dans la cellule-cible, d'une serpine protéinase inhibitrice (SPI)-1, tirée d'un poxvirus. Une SPI-2 peut être éventuellement exprimée dans la cellule en plus de SPI-1. Les cellules exprimant ces protéinases inhibitrices sont résistantes à l'élimination à médiation cellulaire et à l'apoptose.

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