Method for inhibiting cytokine production by cells

Details Method for inhibiting cytokine production by cells Method for inhibiting cytokine production by cells

A - Human Necessities

61

K

A61K 31/655 (2006.01)

Patent

CA 2312023

The invention concerns a method for inhibiting cytokine production by cells, in particular animal or human cells, and their secretion, which consists in applying on said cells at least an azo compound derivatives corresponding to formula (I), in which A represents a carboxyl or a group (a); B represents a carboxyl or a group (b); R?1¿, R?2¿, R?3¿ and R?4¿ = H, Hal, OH or a hydrocarbon radical, R?1¿ and R?2¿ as well as R?3¿ and R?4¿ capable of being a heterocyclic ring; X?1¿ and X?2¿ = O or NR?5¿, where R?5¿ = H, Hal, a hydrocarbon radical or a nitro group.

Procédé d'inhibition de production de cytokines par des cellules, notamment animales ou humaines, et de leur sécrétion, comprenant une application sur ces cellules d'au moins un des dérivés azoïques répondant à la formule (I), où A représente un carboxyle ou un groupe (a), B représente un carboxyle ou un groupe (b), R1, R2, R3 et R4 = H, Hal, OH ou un radical d'hydrocarbure, R1 et R2 ainsi que R3 et R4 pouvant former un noyau hétérocyclique, X1 et X2 = O ou NR5, où R5 = H, Hal, un radical d'hydrocarbure ou un groupe nitro.

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